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In 1959, Sir Alfred Hitchcock (Sir Anthony Hopkins) and his wife, Alma Reville (Dame Helen Mirren), are at the top of their creative game as filmmakers amidst disquieting insinuations about it being time to retire. To recapture his youth's artistic daring, Sir Alfred decides his next movie will adapt the lurid horror novel, "Psycho", over everyone's misgivings. Unfortunately, as Sir Alfred self-finances and labors on this movie, Alma finally loses patience with his roving eye and controlling habits with his actresses. When an ambitious friend lures her to collaborate on a work of their own, the resulting marital tension colors Sir Alfred's work, even as the novel's inspiration haunts his dreams.